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This photo is from an aspirate of a pink, ‘warty’ dermal mass of an 8-yr-old, neutered male, Golden Retriever. The picture consists of a cluster of well-differentiated sebaceous epithelial cells that have moderate amounts of blue, vacuolated cytoplasm, round nuclei, and finely stippled chromatin. A few...

A blood smear from a 10-year-old, spayed female, mixed breed dog was evaluated.  The patient was febrile, reluctant to jump in and out of the car, and hyporexic.  Approximately 25% of neutrophils contained rickettsial morulae (see figure for example) that were irregularly round, 1-2 microns, grey with a granular to punctate appearance.  A moderate thrombocytopenia and mild, non-regenerative...

Aspirates from malignant melanomas can have a varied cytologic appearance, ranging from a round cell appearance to clusters of cells suggestive of epithelial origin to individual, fusiform-shaped cells that are non-specific for mesenchymal cell origin.  All three appearances may be present in aspirates from the same tumor.  Making a definitive diagnosis of...

A liver aspirate from a 13-year-old, spayed female, mixed breed dog with increased ‘liver enzymes’.  A cluster of well-differentiated hepatocytes is present (Figure 1).  The cytoplasm is of a thinner density than normal and has a moth-eaten appearance that causes mild cytoplasmic distension.  The background is a...

Aspiratefrom a lymph node from a6.5-year-old, neutered, male cat.The lymph node had been mildly enlargedfor months and had recently started growing.The image consists a few macrophages, three small lymphocytesand twoneutrophils. Several of the macrophages contain 2-4 μm, oval yeast (Histoplasma capsulatum) with a thin, clear,...

Aspirate from a vaginal mass of a 5-year-old, spayed female Golden Retriever that had been rescued from Turkey. The image consists of many red blood cells, a rare neutrophil, and several individual round cells with abundant light gray cytoplasm that commonly contain few to several...

Aspirate from a 1cm, circular, raised pink dermal mass on the pinna of a 3-year-old spayed female Bull terrier. The mass has been present for 1-2 weeks and has grown slightly. The image consists of few red blood cells, very few small lymphocytes and neutrophil,...

Aspirate from a kidney nodule of a 2-year- old spayed female domestic shorthair feline.  The presenting complaint was weight loss and PU/PD.  Blood work revealed moderate azotemia.  On ultrasound, the kidneys were bilaterally enlarged with ill-defined nodules throughout.  A nodule from one kidney was aspirate...

Aspirate from an abdominal mass of a 5-year-old spayed female Shetland Sheepdog. The presenting complaint was anorexia and vomiting for 1.5 weeks. An abdominal radiograph suggested a possible mid-abdominal mass. On ultrasound, a mixed echogenicity liver mass and an extremely large mixed echogenicity abdominal mass...

An 11-year-old spayed female Boston Terrier had a mass removed two months ago, but it was not submitted for histopathologic evaluation. Just caudal to the scar from the previous surgery, a large soft mass is now present, which is possibly the inguinal lymph node. Many...